Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE At the molecular and cellular levels, angiotensin II, the main effector peptide of the system, stimulates key components of atherosclerosis. 12767951 2003
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Angiotensin II (Ang II) regulates the expression of some core clock genes; excess Ang II leads to atherosclerosis advancement. 29590657 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Angiotensin II and its type 1 receptor (AT1R) are both expressed in the adipose tissue and involved in the genesis of atherosclerosis as well as hypertension. 19696781 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE To further elucidate the role of COUP-TFII, we performed DNA microarrays in VEC transfected with the siRNA of COUP-TFII and subsequently stimulated with angiotensin II (AngII) and compared the expression profiles of 112 genes involved in various atherosclerosis-related pathways. 21069739 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE This is a model of hypertension and atherosclerosis because of high angiotensin II and aldosterone levels as a result of the transgenic expression of the entire human renin-angiotensin system. 17909121 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Elevated levels of crosslinked AT1 receptor dimers on monocytes could sustain the process of atherogenesis, because inhibition of angiotensin II generation or of intracellular factor XIIIA activity suppressed the appearance of crosslinked AT1 receptors and symptoms of atherosclerosis in ApoE-deficient mice. 15507206 2004
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Hypoxia in HCASMCs increases leptin expression through the induction of AngII, ROS, and the JNK pathway to enhance atherosclerosis in HCASMCs. 25573199 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Therapeutic disease RGD Hypertension and atherosclerosis rats were treated with GPE nanoparticles carrying AGT shRNA. 22977667 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II type 1 receptor antagonists (AIIA) are beneficial for the prevention of atherosclerosis and diabetic nephropathy suggesting that angiotensin II (Ang II) promotes the development of these diseases. 17487826 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE <b>Conclusion:</b> RDN promoted atherosclerosis in apolipoprotein E-deficient mice infused with angiotensin II associated with upregulation of MMP-2. 28450836 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang-II), a vascular stimulant associated with cardiovascular disease progression, has been demonstrated to be mainly involved in cardiovascular remodeling of atherosclerosis and cardiac hypertrophy. 29369845 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Its effects on ROS production, AP-1 activity, plasminogen activator inhibitor 1 (PAI-1) gene expression, and cellular proliferation and migration were measured in response to high glucose and angiotensin II (Ang II) concentrations, two major factors in the pathogenesis of atherosclerosis in patients with diabetes and hypertension. 15827742 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In conclusion, administration of rAngpt2 attenuated angiotensin II-induced aortic aneurysm and atherosclerosis in ApoE<sup>-/-</sup> mice associated with reduced aortic inflammation and angiogenesis. 27767064 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Mice deficient both in ApoE and in kinin B1 receptor (ApoE(-/-)-B(1)(-/-)) were generated and analyzed for their susceptibility to atherosclerosis and aneurysm development under cholesterol rich-diet (western diet) and angiotensin II infusion. 19618151 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis. 26771341 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE As both a vasoconstrictor and a proinflammatory mediator, angiotensin II (Ang II) is considered a potential link between hypertension and atherosclerosis. 29130930 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Cilostazol Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E-Deficient Mice. 29437572 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis. 30905257 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE The effects of angiotensin II, which may be at least partially genetically mediated, have been implicated in epidemiologic and clinical studies as a risk factor for the development of atherosclerosis. 11177655 2001
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE While adoptive transfer of B cells in Apoe <sup>-/-</sup> /Baffr <sup>-/-</sup> mice reversed atheroprotection in the absence of AngII, infusion of AngII in B cell replenished Apoe <sup>-/-</sup> /Baffr <sup>-/-</sup> mice unexpectedly prevented the progression of atherosclerosis. 28646220 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) infusion promotes the development of aortic aneurysms and accelerates atherosclerosis in ApoE<sup>-/-</sup> mice. 30048944 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT<sub>1</sub>R/ROS/p38 MAPK/ADAM17 pathway. 31390228 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE These findings show that some AngII-mediated pathways are enhanced in FH subjects irrespective of the presence of low-density lipoprotein (LDL), thus contributing to the development and progression of atherosclerosis in these patients. 15662225 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin-Converting Inhibitors and Angiotensin II Receptor Blockers and Longitudinal Change in Percent Emphysema on Computed Tomography. The Multi-Ethnic Study of Atherosclerosis Lung Study. 28207279 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Because both IL-18 and Angiotensin II (Ang II) are implicated in atherosclerosis, our objective was to analyze the role of IL-18 signaling and potential cross-talk with Ang II in VSMC. 15860756 2005